DIM also inhibited the increase of protein levels of inducible nitric oxide synthase. The study found that DIM significantly reduced the release and production of nitric oxide, prostaglandins, interleukin, and other pro-inflammatory mediators. In one rodent study, researchers examined the effects of DIM on mouse macrophages. Research suggests a correlation between chronic inflammation and the growth and proliferation of cancer cells, and several studies have been conducted to determine if DIM has a potential effect on acute and chronic inflammation. By binding to a estrogen receptor, DIM could block excess estrogen in estrogen-dominant persons from binding to estrogen receptors. Multiple studies have suggested that DIM works on estrogen receptors. Through its antiandrogen (anti-DHT) effects 20, DIM may be able to help with hair loss. Women are more prone to osteoporosis after menopause as their bone density decreases dramatically. Bones: Estrogen plays an important role in maintaining bone density.10 Decreased levels of estrogen during menopause can cause thinning of the skin and hair loss. Skin: Estrogen increases the amount of collagen in the skin and promotes skin thickness.9 Modulating estrogen receptors in the brain can help reduce some of menopause’s mood symptoms. Mice without estrogen receptors display depression-like behavior. Brain: In the brain estrogen has an effect on neurons.19Įstrogen receptors are found all over the body: 8 By interacting with estrogen receptors, DIM may be helpful for menopausal symptoms. Depleted levels of estrogen result in the common symptoms of menopause:ĭIM has been shown to act selectively on estrogen receptors, which means that it only activates some estrogen receptors. However, during menopause, estrogen levels decrease as the ovaries stop responding to signals from the pituitary gland. DIM for Menopauseĭuring a normal menstrual cycle, levels of estrogen and progesterone normally oscillate between high and low levels. Hyperandrogenism can lead to symptoms such as hirsutism (increased facial hair growth), acne, and hair loss (androgenetic alopecia).īecause of DIM’s selective estrogen activation and antiandrogen effects, it may be helpful for PCOS symptoms. PCOS causes irregular menstrual periods, insulin resistance, and hyperandrogenism (too much testosterone and other male hormones). This may result in enlarged ovaries and a failure to release eggs regularly, impairing fertility. PCOS is also characterized by the formation of numerous small collections of fluid known as follicles around the ovaries. PCOS or polycystic ovarian syndrome is a hormone disorder involving the sex hormones. Both are present in varying amounts in males and females. Sex hormones can be categorized into two basic categories, female hormones like estrogen and progesterone and male hormones like testosterone. The difference with DIM is that it supports clearer skin from the inside. There are many acne products on the market, from creams to facial scrubs, toners to acne soaps. 5 This effects may be helpful in decreasing sebum production in acne-prone men and women. 4ĭIM was found to have antiandrogen effects. They stimulate increased sebum production which contributes to acne. 3 Androgens (such as testosterone) are male hormones which occur in the bodies of men and women. While research has yet to determine a singular physiological cause for acne or why some are more predisposed to acne, there are a variety of factors that may contribute to acne, including genetics, your environment, and the food you eat.ĭIM is particularly beneficial for hormonal acne – the type which occurs during times of hormonal fluctuations, such as adolescence and menopause. 1ĭiindolylmethane (DIM) is a plant compound found in cruciferous vegetables such as broccoli, cabbage, Brussel sprouts, cabbage, and kale.ĭIM as the ability to interact with both estrogen and testosterone receptors and may help support hormonal balance. Hormonal imbalance contributes to problems such as acne, menopause/PCOS in women, and estrogen dominance in men and women. Research also shows promising anti-tumor activity of DIM. Women with PCOS often have hormonal imbalances that cause hirsutism (unwanted hair growth on the face and body) and acne. DIM benefits include supporting a healthy menopausal transition, promoting hormonal balance in those with polycystic ovarian syndrome (PCOS). DIM has shown to have a number of health benefits.
0 Comments
Leave a Reply. |